One broader issue here is how easily a complex hormonal condition gets reduced to the most visible variable, when symptoms that persist despite healthy habits can be a signal to investigate the underlying physiology rather than intensify the lifestyle prescription.
Exactly, we should not treat people’s weight but the underlying physiology - regardless of what it is - weight is just a measure that I we somehow became obsessed with
Thanks for this, Fran. The twin data backs this up well! The Netherlands Twin Register study found 71% concordance in identical twins against 38% in non-identical twins, giving a heritability estimate around 0.66 to 0.79 depending on which features are included... The normal-BMI figure also varies hugely by population, from about 62% in a UK cohort of 1,741 women down to a much smaller share in some other countries, so lean PMOS is common but its exact rate depends heavily on where the study was done!
100% and on the BMI front, we need to remember that most of the times when they recruit for these studies they go to places where it’s easy to find PMOS candidates (often clinics of IFV centers) so there is a bias in the selected population - there a new study published showing that when looking at an unselected population somewhere up to 50% are within normal BMI - i will do a post on this later. So much to break apart!
One broader issue here is how easily a complex hormonal condition gets reduced to the most visible variable, when symptoms that persist despite healthy habits can be a signal to investigate the underlying physiology rather than intensify the lifestyle prescription.
Exactly, we should not treat people’s weight but the underlying physiology - regardless of what it is - weight is just a measure that I we somehow became obsessed with
Thanks for this, Fran. The twin data backs this up well! The Netherlands Twin Register study found 71% concordance in identical twins against 38% in non-identical twins, giving a heritability estimate around 0.66 to 0.79 depending on which features are included... The normal-BMI figure also varies hugely by population, from about 62% in a UK cohort of 1,741 women down to a much smaller share in some other countries, so lean PMOS is common but its exact rate depends heavily on where the study was done!
100% and on the BMI front, we need to remember that most of the times when they recruit for these studies they go to places where it’s easy to find PMOS candidates (often clinics of IFV centers) so there is a bias in the selected population - there a new study published showing that when looking at an unselected population somewhere up to 50% are within normal BMI - i will do a post on this later. So much to break apart!