I was interested to see your note that Chromium can help with insulin resistance so looked further into this. The Linus Pauling Institute, notes “Evidence that supplemental chromium can help treat metabolic syndrome or polycystic ovary syndrome is largely lacking.” I am curious what source you found noting it helps? https://lpi.oregonstate.edu/mic/minerals/chromium
controls. Here some studies showed significant reductions in HOMA-IR and HOMA-B but
results varied significantly between studies in some showing no impact (especially on the fasting insulin levels from above)
3. Lastly, there is an interesting study done on gene expression for women who were candidates for IVF. They found improving gene expression of PPAR-γ, GLUT-1, LDLR, and IL-1. Some these are related to insulin resistance and some to inflammation. https://pubmed.ncbi.nlm.nih.gov/30546347/
Overall my take on this is that The Linus Pauling Institute could be right. There is no consistent proof that it can help but in some cases it does. My assumption would be that it depends on the severity of insulin resistance. I would not recommended as point blank supplement (I would not recommend any as a standard)
I have sent you an email with some more info on supplements.
I was interested to see your note that Chromium can help with insulin resistance so looked further into this. The Linus Pauling Institute, notes “Evidence that supplemental chromium can help treat metabolic syndrome or polycystic ovary syndrome is largely lacking.” I am curious what source you found noting it helps? https://lpi.oregonstate.edu/mic/minerals/chromium
Hello Molly, thank you so much for your question. I love receiving these.
There a few systemic reviews that show a positive impact on insulin.
1. https://www.sciencedirect.com/science/article/abs/pii/S0946672X17300755?via%3Dihub - this one over here looked at 7 RCTs including total of 351 participants. It shows a small but significant impact on fasting insulin levels -0.33 mIU/ml - a modest reduction
2. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-101835 - this one looked at 5 studies with reported data on 137 women with PCOS and 131
controls. Here some studies showed significant reductions in HOMA-IR and HOMA-B but
results varied significantly between studies in some showing no impact (especially on the fasting insulin levels from above)
3. Lastly, there is an interesting study done on gene expression for women who were candidates for IVF. They found improving gene expression of PPAR-γ, GLUT-1, LDLR, and IL-1. Some these are related to insulin resistance and some to inflammation. https://pubmed.ncbi.nlm.nih.gov/30546347/
Overall my take on this is that The Linus Pauling Institute could be right. There is no consistent proof that it can help but in some cases it does. My assumption would be that it depends on the severity of insulin resistance. I would not recommended as point blank supplement (I would not recommend any as a standard)
I have sent you an email with some more info on supplements.